Decreased 25-Hydroxyvitamin D Level Is Linked to Anemia in Peritoneal Dialysis Patients

Abstract

Background: 25-Hydroxyvitamin D (25(OH)D) deficiency is the most common complication of kidney disease. Previous studies have suggested that 25(OH)D deficiency is involved in the pathogenesis of anemia in kidney disease subjects not requiring dialysis. However, these associations have not been investigated in peritoneal dialysis (PD) patients. Objectives: The aim of this study was to elucidate the prospective relationship between 25-Hydroxyvitamin D insufficiency and anemia in PD Patients.Materials and Methods: In a cross-sectional study, 80 PD participants were included. Participants were divided into two groups based on baseline 25(OH)D3 concentrations: group 1, 25(OH)D3 levels <10 ng/mL; and group 2, 25(OH)D3 levels ≥ 10 ng/mL. We recorded basic data of subjects. Peripheral blood samples were collected to determine the level of 25(OH)D and hepcidin by the competitive ELISA method. Results: Pearson’s correlation analysis and multivariate linear regression analysis showed that hemoglobin concentration was positively correlated with serum 25(OH)D3 level, p<0.01). Even after adjusting for potential risk factors for anemia, serum 25(OH)D were found to be still associated with anemia (β=1.264; 95% CI=0.992-1.612, P=0.048). Meanwhile, Pearson’s correlation analysis revealed that serum 25(OH)D3 level negatively affect the level of Hepcidin and hs-CRP (p<0.001). We also observed that Hepcidin and hs-CRP negatively regulate Hb level (p<0.001).Conclusions: These findings indicate that 25(OH)D insufficiency was significantly associated with anemia in patients with PD, which, at least in part, was related with the hepcidin level and inflammation.