Abstract

Cholesterol, apolipoproteins A1 and B and triglycerides were evaluated before, during and after extracorporeal circulation during cardiac surgery to a precise degree and chronology of variations. Cholesterol, apolipoprotein B and triglycerides show a significant and persistent decrease following initiation of extracorporeal circulation. Triglycerides decrease is due to factors such as heparin administration. Cholesterol and apolipoprotein B decrease does not appear to be due either to contact with extracorporeal circulation circuit nor hypothermia. Decrease of hepatic VLDL and HDL production or modifications of LDL-cholesterol cell clearance are possible explanations.

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