Abstract
The effect of dietary thiamin deficiency on high affinity [ 3H]ouabain binding was examined in different regions of rat brain. The binding activity in the cerebellum and hypothalamus was significantly lower in the thiamin-deficient group than in the pair-fed control and freely fed control groups. The decrease was due to a change in B max but not in K d. The results suggest a possible involvement of (Na +, K +)-ATPase in neurological manifestations of thiamin deficiency.
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