Decrease Levels of Matrix Metalloproteinase-8 after Adduction of Erythromycin to Periodontitis patients: A Narrative Review

Abstract

Periodontitis is a chronic bacterial infection that affects the gingiva and tooth supporting tissue, causing inflammatory-immune disorders. Matrix metalloproteinase-8 (MMP-8) is a kind of protease that is implicated in the case of periodontitis and can be used in the role of a biomarker. Erythromycin is a type of antibiotic that can be used to treat a variety of bacterial diseases, such as periodontitis. This study aimed to observed that patients with periodontitis have higher levels of matrix metalloproteinase-8 can be reduced with erythromycin. Article references were searched from multiple sources such as google scholar, sciencedirect, NCBI, and Pubmed. The review employed the approach to compare the literature using the same keywords, then came to conclusions. The discovered theories are then summarized in a continuous sequence so that readers can better understand the ideas and advances presented. There were 46 articles from google scholar, sciencedirect, NCBI, and Pubmed that related to diverse literatures. Overall, these results indicate that in periodontitis patients, erythromycin can inhibit MMP 8 production. In periodontitis patients, the medication erythromycin can suppress the synthesis of matrix metalloproteinase-8 (MMP-8) and hence the inflamation.