Abstract
BackgroundIn the clinical setting, chronic rhinosinusitis with nasal polyps (CRSwNP) is usually divided into eosinophilic‐CRS (ECRS) and non‐ECRS (NECRS) in Japan. Patients with the former are believed to be at risk for postoperative recurrence of CRS. However, some patients have been missed according to these phenotypic classifications due to the low number of infiltrating eosinophils in polyp tissues.ObjectiveIn the present study, we attempted to identify cellular or molecular candidate markers to predict nasal polyp recurrence.MethodsNasal polyps were collected from 32 patients with CRSwNP who had undergone an endoscopic sinus surgery. These patients were divided into ECRS and NECRS groups in accordance with the Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis (JESREC) scoring system and the number of eosinophils in polyp tissues. Unclassifiable patients were referred to as the unknown group.ResultsEosinophil infiltration in resected nasal polyps was most evident in the ECRS group. However, the number of mast cells and tryptase‐positive cells in nasal polyps were significantly lower in ECRS and unknown groups compared with the NECRS group. A significant positive correlation was detected between the JESREC score and number of eosinophils. The numbers of mast cells and tryptase‐positive cells were negatively correlated with the JESREC score in all included samples. Significant positive correlations were detected between the number of transforming growth factor β1‐positive cells and the number of mast cells, tryptase‐positive cells, and chymase‐positive cells mast cells.Conclusions and clinical relevanceThese findings indicated that the enumeration of mast cells in resected polyps may be another approach to predict postoperative polyp recurrence in CRSwNP patients.
Highlights
Rhinosinusitis is an inflammation or swelling of nasal mucous membranes and usually starts with cold‐like symptoms such as a runny, stuffy nose, and facial pain
When we evaluated these patients by using the JESREC scoring system, 17 and 8 patients met the criteria for ECRS and NECRS, respectively
Some chronic rhinosinusitis with nasal polyps (CRSwNP) patients are still missed by this diagnostic system mainly because they present with too few eosinophils in polyp tissues
Summary
Rhinosinusitis is an inflammation or swelling of nasal mucous membranes and usually starts with cold‐like symptoms such as a runny, stuffy nose, and facial pain. Chronic rhinosinusitis with nasal polyps (CRSwNP) is usually divided into eosinophilic‐CRS (ECRS) and non‐ECRS (NECRS) in Japan. Patients with the former are believed to be at risk for postoperative recurrence of CRS. Methods: Nasal polyps were collected from 32 patients with CRSwNP who had undergone an endoscopic sinus surgery These patients were divided into ECRS and NECRS groups in accordance with the Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis (JESREC) scoring system and the number of eosinophils in polyp tissues. Conclusions and clinical relevance: These findings indicated that the enumeration of mast cells in resected polyps may be another approach to predict postoperative polyp recurrence in CRSwNP patients
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
