Abstract
背景与目的核心蛋白聚糖（decorin）是细胞外基质（extracellular matrix, ECM）的组成成分，参与抑制胶原纤维形成、调控细胞的增殖和粘附等过程。本研究检测非小细胞肺癌（non-small cell lung cancer, NSCLC）患者肿瘤组织中decorin的蛋白水平，并研究其作为肿瘤抑制因子与各临床指标的关系及其意义。方法采用Western blot方法检测16例肺鳞癌患者的肿瘤组织及其配对正常肺组织中decorin蛋白水平。采用免疫组织化学染色的方法检测51例NSCLC患者的肿瘤组织和正常肺组织中decorin蛋白水平。结果Western blot结果表明相对于癌旁肺组织，12例（75.0%）肺癌组织中decorin的蛋白表达水平明显下调。Decorin在肺癌的肿瘤组织表达阳性率仅为11.8%，明显低于正常肺泡组织（阳性率为53.1%，P < 0.001）。并且，decorin在肺腺癌组织中几乎不表达（阳性率为0），与肺鳞癌组织相比有统计学差异（阳性率为24.0%，P=0.006）。结论NSCLC肿瘤组织中decorin蛋白水平明显降低并与病理类型相关，提示decorin的异常下调可能在肺腺癌的发生发展过程中发挥作用。
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