Abstract
The prevalence of sickle cell disease (SCD) is high in the southwest region of Saudi Arabia. Liver involvement in patients with SCD represents a challenging medical problem in clinical practice and carrying a high morbidity and mortality rates. We reported two cases of young patients (19 year male and 22 year female), both of them were known to be non-blood transfusion SCD patients. They have had almost the same clinical presentation with advanced decompensated liver cirrhosis and severe progressive jaundice. Early screening of SCD patients for iron overload, beside commencement of iron chelating agents can prevent the long-term sequel of iron overload.
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