DECOMPENSATED CHRONIC HEART FAILURE COURSE IN DIABETES PATIENTS

Abstract

Aim. To investigate on clinical, hemodynamic and laboratory specifics of heart failure course in diabetes mellitus type 2 (DM2) patients and non-diabetic, hospitalized due to acute decompensation of chronic heart failure (CHF). Material and methods. Totally, 134 patients included, hospitalized to cardiology. All patients were selected to 2 groups: I (CHF and DM2, n=66; age 61,8±7,2 y. o., 28 males, 38 females), and group II (CHF non-DM, n=68; 62,3±7,7 y. o., 33 males, 35 females). Symptom assessments were done, with the score of clinical state in CHF (SCSC), electrocardiography (ECG) resting in 12 leads; transthoracal echocardioscopy; laboratory blood tests; chest x-ray; 6-minute walking test. Results. Patients with CHF and DM2 were characterized by comparatively high functional class of CHF, severity of symptoms (by SCSC 13,7±2,2 versus 11,1±2,2 points, p<0,05) and more prominent morphofunctional changes of the heart: significant decrease in ejection fraction of the left ventricle (LV) by 5,5% and increase of deceleration time in early diastolic filling, followed by the decrease of E/A. The specifics found was followed by disordered biochemical parameters in DM2. Anamnesis of CHF and DM2 in the cohort made it to find out an insufficient (less than 80%) control of glycemia among CHF and DM2 patients regardless long lasting course of glycemia disorder. Conclusion. Results of the conducted study demonstrate negative character of impact of DM2 on CHF course of ischemic and non-ischemic origin.