Decoding Protein Gas‐Phase Stability with Alanine Scanning and Collision‐Induced Unfolding Ion Mobility Mass Spectrometry

Abstract

AbstractInvited for this month's cover are the collaborating groups of Professor Neil Oldham at the University of Nottingham and Dr. Matthew Jenner at the University of Warwick, UK. The cover picture shows collision induced unfolding (CIU) of an acyl carrier protein in the gas‐phase as measured by ion mobility spectrometry. The background shows a representation of the alanine scanning mutagenesis used to probe the importance of individual residues in stabilising the compact form of the protein. Read the full text of the article at 10.1002/anse.202000019.