Decoding of Single Auditory Features Investigated by Mismatch Negativity

Abstract

Event Abstract Back to Event Decoding of Single Auditory Features Investigated by Mismatch Negativity Melissa Larsen1, 2*, Morten Mørup2, Michelle Rosgaard Birknow3, 4, Elvira Fischer1, 5, William Baaré1, Thomas Werge5 and Hartwig Siebner6, 7 1 Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital, Danish Research Centre for Magnetic Resonance, Denmark 2 Technical University of Denmark, DTU Compute, Denmark 3 H. Lundbeck A/S, Synaptic Transmission 2, Denmark 4 University of Copenhagen , Department of Neurology, Psychiatry and Sensory Sciences, Denmark 5 Mental Health Centre Sct. Hans Copenhagen University Hospital, Research Institute of Biological Psychiatry, Denmark 6 Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital, Danish Research Centre for Magnetic Resonance, Denmark 7 Bispebjerg Hospital, University of Copenhagen, Department of Neurology, Denmark A fundamental task our brain successfully masters on a daily basis is to detect unexpected changes in our environment. This process can be studied electrophysiologically with electroencephalography (EEG) by measuring the event related response to auditory irregularities in a stream of standard tones. Such irregularities give rise to the so-called mismatch negativity (MMN), an evoked fronto-central response emerging 100 - 150 ms after onset of an oddball stimulus (R. Naatanen et. al 2007). Previous studies used a classical oddball paradigm to test up to five different deviant types within one paradigm, but failed to investigate the memory trace effect for each of the different oddballs and how this leads to the prediction of sensory changes. Here we propose a multiplex MMN roving paradigm, independently introducing pitch and duration deviants, which then become the new standard within their domain, pitch and duration respectively. This paradigm evokes specific responses to distinct auditory changes and allows to characterize the memory trace to single auditory features. We successfully separated the frontal MMN responses to pitch from duration deviants within our multiplex roving paradigm in healthy human subjects. We compared these signals to responses from a pure pitch roving paradigm using a simple parametric comparison between the standards and the deviants. Our results show similar MMN prefrontal responses to pitch in the pure pitch and the multiplex paradigm. This is in line with previous studies on mismatch negativity and predictive coding suggesting prefrontal regions to play a role in integrating bottom-up sensory signals with top-down predictive signals (Rao and Ballard, 1999). Further, our results imply that single auditory features are decoded independently from each other and hence our findings may contribute to the characterization of change detection responses in the human cortex. Keywords: EEG, predictive coding, auditory processing, MMN, change detection Conference: XII International Conference on Cognitive Neuroscience (ICON-XII), Brisbane, Queensland, Australia, 27 Jul - 31 Jul, 2014. Presentation Type: Poster Topic: Sensation and Perception Citation: Larsen M, Mørup M, Rosgaard Birknow M, Fischer E, Baaré W, Werge T and Siebner H (2015). Decoding of Single Auditory Features Investigated by Mismatch Negativity. Conference Abstract: XII International Conference on Cognitive Neuroscience (ICON-XII). doi: 10.3389/conf.fnhum.2015.217.00217 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 19 Feb 2015; Published Online: 24 Apr 2015. * Correspondence: Ms. Melissa Larsen, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital, Danish Research Centre for Magnetic Resonance, Hvidovre, Denmark, melissal@drcmr.dk Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Melissa Larsen Morten Mørup Michelle Rosgaard Birknow Elvira Fischer William Baaré Thomas Werge Hartwig Siebner Google Melissa Larsen Morten Mørup Michelle Rosgaard Birknow Elvira Fischer William Baaré Thomas Werge Hartwig Siebner Google Scholar Melissa Larsen Morten Mørup Michelle Rosgaard Birknow Elvira Fischer William Baaré Thomas Werge Hartwig Siebner PubMed Melissa Larsen Morten Mørup Michelle Rosgaard Birknow Elvira Fischer William Baaré Thomas Werge Hartwig Siebner Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.