Decoding force production of skeletal muscle from the female brain using functional near-infrared spectroscopy.

Abstract

Noninvasive neural decoding enables predicting motor output from neural activities without physically damaging the human body. A recent study demonstrated the applicability of functional near-infrared spectroscopy (fNIRS) to decode muscle force production from hemodynamic signals measured in the male brain. However, given the sex differences in cerebral blood flow and muscle physiology, whether the fNIRS approach can also be applied to the female brain remains elusive. Therefore, this study aimed to evaluate whether fNIRS can be used to identify the optimal cortical region and hemodynamic predictor to decode muscle force output in females. Statistical group analysis for eight healthy female adults showed that the cortical region for wrist control was topologically dorsal to that for finger control over the primary sensorimotor cortex. This cortical area was maximally activated while the wrist flexor muscles were contracted to hold a load on the subject's palm, as was the case for males. However, the dynamics of oxyhemoglobin concentration measured from the most activated cortical area differed between females and males. The signal intensity during 100% maximal voluntary contraction and the signal increase rate at 50% maximal voluntary contraction was lower and faster in females. Eight predictors were used to characterize hemodynamic signals' amplitude and temporal variation in the female cortex. Unlike the case for males, only the trajectory predictors for the amplitude of oxyhemoglobin concentration change were strongly correlated with the strengths of force produced by the wrist flexor muscles, showing a linear relationship. These results suggest gender-specific hemodynamics must be considered for decoding low-level motor control with fNIRS in females.