Decoction of ginger (Zingiber officinale Roscoe var Roscoe) attenuate the oxidation stress in hyperlipidemia rat (Rattus norvegicus)

Abstract

Based on UNICEF data, overweight and obesity increased across all age and income groups. Overweight has a risk of developing hyperlipidemia and caused increase free radical and lead to oxidative stress. It’s result in cell damage and impacts on several diseases among others diabetes mellitus. Many Medicinal Plant have biochemical compound which is an important concern because of the potential to reduce free radicals. 0ne of them is ginger (Zingiber officinale Roscoe var Roscoe). Medicinal plant generally is usually used with various extraction method to obtain the required chemical content. Information of ginger for reduce free radical with maceration extraction method has been reported in previous studies but little information with decoction extraction method. This study aims to determine the reduction of free radicals with MDA (malondialdehyde) as a marker and increased antioxidant activity with SOD (superoxide dismutase) as a marker after administration of ginger. This research was used the true experimental with the randomized posttest only control group design. The groups of experimental were divided into three which G1: control normal G2: High Fat Diet (HFD), G3: HFD + Zingiber officinale Roscoe var Roscoe (ZO) 5 g/day. The period of study was 6 weeks. The level of liver MDA and SOD were investigated by spectrophotometer UV Vis. Based on ANAVA showed that HFD rat increase of body fat weight and MDA (p<0,05) and reduced of total antioxidant SOD (p<0.05). The conclusion of this research decoction of Zingiber officinale Roscoe var Roscoe could attenuate of lipid peroxidation induce by HFD.