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Abstract
Declining pattern of bilirubin in the first and second six hours of intensive versus double phototherapy in neonatal jaundice
Highlights
Phototherapy has been used in clinical practice for 50 years, there is still much debate about how the most efficacious phototherapy application can be provided
The mean serum bilirubin decline in intensive phototherapy (IP) group was statistically significant in comparison with double phototherapy (DP) group in the first 6 hours of phototherapy (4.65 ± 2.02 mg/ dl versus 3.59 ± 1.86 mg/dl, P=0.008)
As there was no difference between DP and IP in the rate of bilirubin decline in the second 6 hours of phototherapy, DP can be used instead of IP if total bilirubin is high but under exchange transfusion level in the second 6 hours of phototherapy
Summary
Phototherapy has been used in clinical practice for 50 years, there is still much debate about how the most efficacious phototherapy application can be provided. Neonatal hyperbilirubinemia is one of the most common diseases worldwide and can be treated effectively by phototherapy [1,2]. It is usually benign in term and preterm neonates [3], severe hyperbilirubinemia is a medical emergency because bilirubin is neurotoxic substance [4] that can cause neurologic defects [5]. For several decades phototherapy has been known as a standard therapy for neonatal hyperbilirubinemia [6]. Some variables like wave length of light, energy output or irradiance, exposed surface area to the light, the distance between the body and the source of radiation may influence the efficacy of phototherapy [7]. Several studies have been done to compare the efficacy of different modes of phototherapy [9]
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