Declined plasma sfrp5 concentration in patients with type 2 diabetes and latent autoimmune diabetes in adults.

Liqing Cheng,Bing Chen,Dongmei Zhang

doi:10.12669/pjms.313.6964

Abstract

Objective:Secreted frizzled-related protein 5 (sfrp5), like adiponectin, has been identified as a novel insulin-sensitising and anti-inflammatory adipokine. Our objective was to determine whether differences of circulating plasma sfrp5 concentration exist among type 2 diabetes (T2D), latent autoimmune diabetes in adults (LADA) and healthy population.Methods:Enzyme-linked immuno sorbent assay was employed to detect the circulating sfrp5 level in plasma, and other lab tests such as fasting glucose and creatinine were also examined. Correlation analysis between sfrp5 and characteristics of subjects was conducted IBM SPSS Statistics and GraphPad Prism.Results:Circulating sfrp5 level was significantly decreased in T2D and LADA patients plasma compared with that in healthy control (14.14±11.91ng/mL, 14.82±11.27ng/mL, 22.98±12.36ng/mL, respectively), although no differences was observed between LADA and T2D groups. Furthermore, we found sfrp5 was correlated with homeostasis model assessment of insulin resistance (HOMA-IR), diabetes duration and BMI. Finally we found sfrp5 was still negatively correlated with HOMA-IR after being adjusted for disease duration and BMI(r= -0.315, P< 0.05).Conclusions:Our results support a role for SFRP5 as a protective factor in the pathogenesis of autoimmune diabetes and facilitate a novel aspect for diabetes research.

Highlights

Clinical and molecular studies have offered clear evidence for the role of diet-induced chronic low-grade inflammation as an important link1
Body mass index (BMI), SBP, FPG, fasting insulin (FINS), homeostasis model assessment of insulin resistance (HOMA-IR), total cholesterol (Tch) and high-density lipoprotein cholesterol (HDL-C) were increased in the type 2 diabetes population compared with those of healthy controls; BMI, FPG, FINS, Cr and HDL-C were increased in the Latent autoimmune diabetes in adults (LADA) population compared with those of healthy controls; type 2 diabetes group exhibited a significantly higher diabetes duration, BMI, SBP, FINS, HOMA-IR, urea nitrogen (UN) and Cr, respectively, than those of LADA population
In accordance with major results, patients with type 2 diabetes had declined plasma sfrp5compared with health control population (14.14±11.91ng/mL, 22.98±12.36ng/ mL, respectively).[15,17]

Summary

Introduction

1. Liqing Cheng, Department of Endocrinology and Metabolism, 2. Bing Chen, Department of Endocrinology and Metabolism, 1-3: Southwest Hospital, Third Military Medical University, Chongqing, China, 400038. Correspondence: November 27,204 December 4, 2014 March 14, 2015 between obesity and type 2 diabetes (T2D) and a wealth of pro-inflammatory and anti-inflammatory cytokines were associated.[1,2,3] there is even a debate on T2D as an autoimmune disease, a hypothesis both metabolic and adipocyte stress acting via pro-inflammatory cytokines and inflammatory signaling followed by T cells, B cells and macrophages activated.[4,5] Latent autoimmune diabetes in adults (LADA), a condition that shares many features with type 1 diabetes and is often misdiagnosed as type 2 diabetes, is well known as a autoimmune disease,[6] it’s association with pro-inflammatory and anti-inflammatory cytokines is few and controversial.[7,8,9]

Methods

Results

Conclusion