Decline in the integration of top-down and bottom-up attentional control in older adults with mild cognitive impairment

Abstract

Individuals with mild cognitive impairment (MCI) have deficits in goal-directed top-down and stimulus-driven bottom-up attentional control. However, it remains unclear whether and how the interaction between the two processes is altered in individuals with MCI. We collected electroencephalography (EEG) data from 30 older adults with MCI and 30 demographically matched healthy controls (HCs) when they were performing a perceptual decision-making task, in which we manipulated the cognitive load involved in task-relevant top-down processing and the surprise level involved in task-irrelevant bottom-up processing. We found the significant group difference in the interaction between top-down and bottom-up processes. HCs showed enlarged P3 and strengthened event-related microstate C on high (vs. low) surprise level trials under high cognitive load, while there was no such surprise effect suggesting distraction under low cognitive load. In contrast, participants with MCI showed increased P2 and P3 amplitudes and strengthened microstates C and D on high (vs. low) surprise level trials under low cognitive load yet no surprise effect under high load. These results suggested that participants with MCI were distracted by task-irrelevant information under low cognitive load, while under high load, they might experience a passive inhibition on the task-irrelevant bottom-up processing because of the exhaustion of attentional resources; in addition, this altered interaction observed in the MCI group occurred at the stages of selective attention and uncertainty reduction.