Abstract
The decrease in the rate of protein synthesis in aging adult Drosophila melanogaster was found previously to be due, to a great extent, to a drop in the rate of peptide chain elongation, and principally to lowered activity of elongation factor one (EF-1). This decrease does not appear to be caused by appearance of an inhibitor of peptide chain elongation. Instead, the synthesis of EF-1 declines markedly early in adult life. This decrease is followed by lowered activity of EF-1 and by a drop in the synthesis of most of the cellular proteins.
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