Abstract
To the Editor. — Colice is to be commended for his meticulous effort, through the use of decision analysis,1to resolve the controversy regarding isoniazid chemoprophylaxis for young purified protein derivative (PPD) reactors of unknown date of conversion, with a normal chest roentgenogram, and with no additional risk factors for developing tuberculosis. As he notes, three previous decisionanalysis studies have reached conflicting conclusions. With the addition of the current study, the "score" now stands as two1,2favoring the American Thoracic Society/Centers for Disease Control recommendation, and two3,4failing to support it. In all of these studies,1-4the decision trees are similar in design in that the "no isoniazid" limb is followed by a "tuberculosis—no tuberculosis" chance node. What is missing in terms of clinical relevance is a "risk factorno risk factor" branch pointpriorto the possible development of tuberculosis. Those physicians who advocate not giving
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.