Abstract
MicroRNAs (miRNAs) are small non-coding RNA molecules that control the post-transcriptional gene expression. They play a pivotal role in the regulation of important physiological processes. Variations in miRNA genes coding for mature miRNA sequences have been implicated in several diseases. However, the association of variants in miRNAs genes with Type 2 Diabetes Mellitus (T2DM) in the Pakistani population is rarely reported. Therefore, the current study was designed to investigate the association of rs11614913 T/C (MIR196A2), rs2910164 G/C (MIR146A), and rs6505162 C/A (MIR423) in clinicopathological proven T2DM patients and gender-matched healthy controls. The tetra-primer amplification refractory mutation system-polymerase chain (ARMS-PCR) reaction method was used to determine the genotypes and to establish the association of each variant with T2DM through inherited models. In conclusion, the present study showed that variants rs11614913 T/C and rs2910164 G/C were linked with the risk of T2DM. The data suggested that rs11614913 T/C and rs2910164 G/C could be considered as novel risk factors in the pathogenesis of T2DM in the Pakistani population.
Highlights
Introduction iationsDiabetes Mellitus (DM) is a group of metabolic disorders categorized by high glucose levels in the blood
DM is characterized by hyperglycemia due to insufficient production of insulin or insulin resistance or both [1]
A strong association was found between the C allele of rs11614913 T/C (MIR196A2) and increased risk of Type 2 Diabetes Mellitus (T2DM)
Summary
Diabetes Mellitus (DM) is a group of metabolic disorders categorized by high glucose levels in the blood. DM is characterized by hyperglycemia due to insufficient production of insulin or insulin resistance or both [1]. The World Health Organization (WHO) further classified DM into four sub-groups: T1DM, T2DM, Gestational Diabetes Mellitus (GDM), and Maturity-onset diabetes of youth (MODY). According to the international diabetic survey, in 2019, about 19.4 million people were diagnosed with diabetes in Pakistan [2,3]. It is one of the leading causes of death in Pakistan. The estimated incidence of diabetes is higher in an urban area (28.3%) than in a rural area (25%).
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
