Abstract
Hodgkin’s disease (HD) accounts for approximately 11% of all malignant lymphomas. Sperm banking is offered to cancer patients prior to cancer treatment. Low production of male hormones, and disturbed spermatogenesis results in oligospermia, olioasthenospermia, oligoasthenoteratospermia and azoospermia in patients with HD prior to treatment. There are no proteomic studies identifying alterations occurring at the spermatogenic level in these patients. The objective of this study was to identify the sperm proteins associated with poor sperm quality in HD patients prior to cancer treatment using Liquid Chromatography (LC)-tandem Mass Spectrometry (MS) and in silico methodologies.
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