Abstract
Neuroblastoma (NB) is a type of peripheral sympathetic nervous system cancer that most commonly affects children. It is caused by the improper differentiation of primitive neural crest cells during embryonic development. Although NB occurs for 8% of paediatric cancers, it accounts for 15% of cancer-related deaths. Despite a considerable increase in cytotoxic chemo- and radiotherapy, patients in advanced stages remain virtually incurable. Therefore, there is a desperate necessity for new treatment strategies to be investigated. Accumulating evidence suggested that microRNAs (miRNAs) are a class of non-coding RNAs with 19–25 nucleotides lengths and play a central role in the development of NB carcinogenesis. Fascinatingly, miRNA inhibitors have an antisense property that can inhibit miRNA function and suppress the activity of mature miRNA. However, many studies have addressed miRNA inhibition in the treatment of NB, but their molecular mechanisms and signalling pathways are yet to be analysed. In this study, we impart the current state of knowledge about the role of miRNA inhibition in the aetiology of NB.
Highlights
Neuroblastoma (NB) is a rare type of solid tumour that arises in the adrenal glands
It is a cancerous tumour made up of undifferentiated neuroectodermal cells that originate from the neural crest
This review mainly focuses on the miRNA inhibition in NB and its role in treatment strategies
Summary
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. Neuroblastoma (NB) is a rare type of solid tumour that arises in the adrenal glands. It is a cancerous tumour made up of undifferentiated neuroectodermal cells that originate from the neural crest. The initial tumour in NB is frequently found in the abdomen, and risk categories are determined by a variety of clinical and molecular variables [3]. Profiling research has found that miRNAs are linked to clinical outcomes in NB [11], and specific miRNAs have been discovered to influence essential processes in NB such as apoptosis, differentiation and cell proliferation [12,13]. The subsequent sections of this paper will go through some of the recent discoveries that have aided in the knowledge of neuroblastoma development and may be used as a therapeutic target
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
