Abstract
Early steps of development are crucial to the emergence and expansion of haematopoieitic stem cells (HSC) as these cells are responsible for the formation of all blood cells throughout life. This research project focuses on the identification of miRNAs that can act as modulators of HSC emergence and expansion during embryonic life. MiRNAs are small non-coding RNAs that modulate the expression of many transcripts simultaneously and their biological role can be cell-type specific. First, we generated a miRNA expression profile of tissues that are involved in HSC emergence and expansion (E11 AGM/Aorta-Gonad-Mesonephros, E11 Yolk Sac, E12 Placenta, E14 Fetal Liver), using Illumina deep sequencing technology.
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