Abstract
The aim of this study is to identify the genetic alteration in SPARC gene family and its association with head and neck squamous cell carcinoma (HNSCC). Head and neck cancer is a set of cancerous lesions arising from the squamous cell of the mucous membrane of the oral cavity, nose throat, larynx and pharynx. SPARC gene encodes for cysteine rich acid matrix metalloprotein, osteonectin whose expression in metastatic OSCC (Oral squamous cell carcinoma) was found to be higher. This expression pattern also correlated with the worst pattern of invasion and differentiation of OSCC tumors. In line with the above facts, the present study was carried out to ascertain the gene alterations and their consequences. Also the putative association of gene alterations with HNSCC was analyzed using computational tools. The Cancer Gene Atlas (TCGA, Firehose Legacy) dataset hosted by the cBioportal server was used in the present study. The non-synonymous variants identified were further assessed for protein stability and pathogenicity employing IMutant and PROVEAN tools. Gene amplification was observed in the FSTL1 gene, which was also shown to present with the highest frequency of gene alterations (5%) among eight genes. Furthermore, the expression of the FSTL1 gene was found to differ significantly among different grades of HNSCC. In conclusion, the study throws light on the possible association of the FSTL1 gene of the SPARC family with HNSCC.
Highlights
Head and neck squamous cell carcinoma (HNSCC) is the most common type of cancer which accounts for more than 6,50,000 cases and 3,30,000 deaths annually
HNSCC represents the cancerous lesions arising from the squamous cell of the mucous membrane of the oral cavity, nose throat, larynx and pharynx [1]
According to the GLOBOCAN survey, 2018, the incidence of HNSCC was found to be clustered in specific regions in the world with a high incidence rate recorded in the south Asian countries [2]
Summary
Head and neck squamous cell carcinoma (HNSCC) is the most common type of cancer which accounts for more than 6,50,000 cases and 3,30,000 deaths annually. HNSCC represents the cancerous lesions arising from the squamous cell of the mucous membrane of the oral cavity, nose throat, larynx and pharynx [1]. According to the GLOBOCAN survey, 2018, the incidence of HNSCC was found to be clustered in specific regions in the world with a high incidence rate recorded in the south Asian countries [2]. While the total number of incidences of HNSCC has reduced since 1975 there can be unusual bleeding, facial swelling, or trouble breathing. The most common etiology of head and neck cancer are tobacco smoking and alcohol consumption. The human papilloma virus (HPV) has emerged as a major cause of HNSCC among non-smokers and light drinkers [4]
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