Abstract
Deciphering New Molecular Mechanisms of Mast Cell Activation
Highlights
Mast cells are tissue-localized effectors of hematopoietic origin
Under the effect of released histamine, vessels become permeable allowing the influx of other inflammatory cells and other inflammatory products into tissues to mount an inflammatory response against the insult
This is followed by a third wave of mediators, which correspond to various cytokines and chemokines allowing to enhance the flow of other inflammatory and immune cells into tissue, and to start to regulate and coordinate this inflammatory response
Summary
Mast cells are tissue-localized effectors of hematopoietic origin. They are prominent in tissues that are in contact with the external environment such as the skin, the gastrointestinal tract, or the airways. Under the effect of released histamine, vessels become permeable allowing the influx of other inflammatory cells and other inflammatory products (such as for example immunoglobulins and complement) into tissues to mount an inflammatory response against the insult.
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