Abstract
Deciphering Cancer and Bone Interactions for Therapeutic Benefits.
Highlights
Understanding the mechanisms responsible for bone metastasis, the abnormalities that occur in the normal bone remodeling process that increase tumor growth and resistance to chemotherapy when cancer involves bone, and how bone serves as a reservoir for dormant tumor cells that can be reactivated to form active metastasis, which can go to distant organs, represent important areas of research
Much progress has been made over the last several years in our understanding of the mechanisms responsible for bone metastasis, the contribution of different cell types in bone to the metastatic process, and the metabolic consequences of bone metastasis. This increased understanding of the bone metastatic process has resulted in identification of new therapeutic targets for preventing and treating bone metastasis, which may be translatable to the clinic
New information is provided on the mechanisms responsible for the prolonged osteoblast suppression that occurs in multiple myeloma, which allows osteolytic lesions to persist even in the absence of active disease
Summary
Bone metastasis is extremely rare in patients with hematologic malignancies, multiple myeloma is the most frequent cancer to involve bone, with up to 90% of patients having bone involvement during the course of their disease. Understanding the mechanisms responsible for bone metastasis, the abnormalities that occur in the normal bone remodeling process that increase tumor growth and resistance to chemotherapy when cancer involves bone, and how bone serves as a reservoir for dormant tumor cells that can be reactivated to form active metastasis, which can go to distant organs, represent important areas of research.
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