Deceleration the hydrolysis reaction of ethyl acetate ester by β-cyclodextrin in basic medium: transition state analog

Abstract

Electrical conductivity measurements were used to study the hydrolysis reaction of dilute aqueous solution of ethyl acetate with the presence β-cyclodextrin (β-CD) within a concentration range between 0.00 and 0.00750 M in basic medium at 25.0 °C. 0.00265 M of β-CD was chosen as typical concentration for studying the same reaction at different temperatures between 21.0 and 35.0 °C. Two different values of activation energy for the hydrolysis reaction of free ethyl acetate and ethyl acetate/β-CD complex were evaluated, and their values are 46.3 and 62.0 kJ mol−1 respectively. The standard Gibbs energy of activation (∆‡Go), standard enthalpy of activation (∆‡Ho), and standard entropy of activation (∆‡So) for the two different cases were evaluated. β-CD plays a notable role in retarding the rate of hydrolysis of ethyl acetate in basic medium.