Abstract
Background: Decalepis hamiltonii (Dh), a climbing shrub belonging to the family Apocynaceae, is consumed for its health-promoting properties. Objective: The present study was designed to evaluate the cardioprotective potential of Dh extract and its bioactive compounds on region-specific responses against isoproterenol (ISO)-induced myocardial injury in male Wistar rats. Materials and Methods: Rats were orally supplemented with ellagic acid (50 mg/kg body weight [BW]), 4-hydroxy isophthalic acid (30 mg/kg BW), and Dh extract (100 mg/kg BW) for 30 days, and they were subsequently administered (intraperitoneally) with ISO (150 mg/kg BW) for the last 2 days. Results: ISO-treated rats showed a significant increase in serum lipid profile, markers of cardiac damage, and decreased antioxidant status. Supplemented groups showed improved lipid profile, reduced serum marker enzymes, and enhanced antioxidant status in ISO-administered rats. Histopathological studies further confirmed the protective effect of Dh extract against ISO-induced myocardial infarction (MI). Conclusion: Our results demonstrated that Dh extract and its compounds efficiently ameliorated ISO-induced MI in rats.
Highlights
Decalepis hamiltonii (Dh), a climbing shrub belonging to the family Apocynaceae, is consumed for its health‐promoting properties
We reported that ellagic acid (EA) and 4‐hydroxy isophthalic acid (4‐HIA) are the major phenolic compounds in the Dh extract, which exhibited protective effects against peroxyl‐induced oxidative stress in the rat erythrocytes
The heart weight (HW) and HW/BW ratio were recorded as an index of cardiac hypertrophy and were significantly increased in ISO‐induced rats with respect to the normal control rats
Summary
Decalepis hamiltonii (Dh), a climbing shrub belonging to the family Apocynaceae, is consumed for its health‐promoting properties. Objective: The present study was designed to evaluate the cardioprotective potential of Dh extract and its bioactive compounds on region‐specific responses against isoproterenol (ISO)‐induced myocardial injury in male Wistar rats. Materials and Methods: Rats were orally supplemented with ellagic acid (50 mg/kg body weight [BW]), 4‐hydroxy isophthalic acid (30 mg/kg BW), and Dh extract (100 mg/kg BW) for 30 days, and they were subsequently administered (intraperitoneally) with ISO (150 mg/kg BW) for the last 2 days. Results: ISO‐treated rats showed a significant increase in serum lipid profile, markers of cardiac damage, and decreased antioxidant status. Supplemented groups showed improved lipid profile, reduced serum marker enzymes, and enhanced antioxidant status in ISO‐administered rats. Histopathological studies further confirmed the protective effect of Dh extract against ISO‐induced myocardial infarction (MI). Conclusion: Our results demonstrated that Dh extract and its compounds efficiently ameliorated ISO‐induced MI in rats.
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