Debunking Chemiosmosis and Proposing Murburn Concept as the Operative Principle for Cellular Respiration

Abstract

Via a concomitant communication (the first part of my work), I have conclusively debunked the prevailing explanations for mitochondrial oxidative phosphorylation and established the need for a novel rationale to account for the reaction paradigm. Towards the same, murburn concept is hereby floated as a viable explanation (in the second part of my work). It is proposed that the inner mitochondrial membrane (harboring the various metal and flavin enzyme complexes) serves as means to confine and stabilize radical reactions, which effectively couple and bring about ATP synthesis in the proton-deficient microcosm. The proposed scheme is un-ordered and favored by Ockham's razor and evolutionary perspectives. Murburn concept is a paradigm-shift in biochemistry because it advocates that diffusible reactive (oxygen) species are mainstay of routine cellular metabolic process within the mitochondria.