Abstract
Death domain-associated protein (DAXX) is a multifunctional protein that modulates both cell death and transcription. DAXX predominantly localizes in the nucleus and regulates the transcription of genes. Several studies have indicated that DAXX is a mediator of lymphocyte death and/or growth suppression, although it is still unclear whether DAXX pro-cell death function is dependent on its transcriptional functions. We found that DAXX suppresses the gp130/STAT3-dependent cell growth and that DAXX interacts with STAT3 and inhibits its DNA-binding activity. Here we will discuss recent developments in our understanding of the nuclear functions of DAXX.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
