Abstract
An analysis of selected datasets from the FDA’s drug Adverse Event Reporting System (FAERS) leads us to hypothesize that glyphosate contamination in both food and drugs is a major contributor to chronic and acute kidney failure respectively. In chronic kidney failure, glyphosate-induced pancreatitis results in the release of trypsin, causing a leaky vasculature. The albumin-bound glyphosate escapes into the tissues, protecting the circulatory system and kidneys but resulting in multiple symptoms related to skin, gut, brain, bones, lungs, etc. The rare and poorly understood acute kidney failure response reported for protamine sulfate and Trasylol? is strikingly similar to that associated with glyphosate poisoning. Both drugs are derived from biological tissues that are plausibly contaminated with glyphosate. These drugs protect from haemorrhage, which leads to retention of glyphosate in the vasculature, are followed by circulatory collapse and a high likelihood of death as an outcome. We support our argument by comparing symptom profiles of selected subsets of FAERS with those related to glyphosate poisoning, anomalous reactions to protamine sulfate, and conditions showing strong statistical time-trend correlations with glyphosate.
Highlights
Adverse drug reactions are common among intravenous medications, especially those administered to intensive care unit (ICU) patients [1]
We propose that renal failure with adrenal insufficiency captures chronic renal failure and associated symptoms due to chronic glyphosate exposure from food, and that the TRASYLOL-associated renal failure subset is far more likely to reflect glyphosate contamination in the drug, especially when the drug in question (TRASYLOL and PROTAMINE SULFATE) protects from haemorrhage
In the case of Swanson et al [32], the conditions with weak support in the HDA DRUGS dataset are multiple sclerosis, Parkinson’s disease, inflammatory bowel disease and viral infection. We propose that these conditions, all of which are well supported in the adrenal insufficiency dataset, are linked to chronic exposure of the gut microbiome to glyphosate via an oral delivery pathway, whereas intravenous administration of glyphosate through drug contamination would by-pass the gut
Summary
Adverse drug reactions are common among intravenous medications, especially those administered to intensive care unit (ICU) patients [1]. The US Food and Drug Administration’s (FDA’s) Adverse Event Reporting System (FAERS) database is a large collection of drug side effect reports dating back to 2004. While it contains a wealth of information, it is difficult to tease out from the data the cause-and-effect relationships. This is mainly because most of the entries contain multiple drugs and multiple side effects, and some of the drugs are long-term maintenance drugs that may be irrelevant to the event. Many of the side effects mentioned are likely preconditions such as diabetes or heart disease, which are probably provided to give additional useful information about the patient, but they contribute noise to the task of sorting out cause-and-effect relationships
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