Dead end and Detour: The function of the RNA-binding protein Dnd in posttranscriptional regulation in the germline.

Abstract

Posttranscriptional regulation is a key part of controlling gene expression in different cell types, in particular in the context of specification, maintenance and differentiation of germline cells. A central regulator of these processes is the vertebrate protein Dead end (Dnd). This RNA-binding protein is important for the survival and preservation of the fate of primordial germ cells (PGCs) and for subsequent development of the male germline. In this chapter, we review the biological and molecular functions of the protein and suggest a model that takes into account the diverse roles described for Dnd in the germline. According to this model, Dnd functions as a scaffold that can bind a wide range of RNA molecules and, at the same time, provides a platform for a variety of proteins that affect posttranscriptional processes such as RNA stability and translation. This scenario offers a mechanistic basis for the control of diverse molecular processes in different contexts in germline development by the Dnd protein.