Abstract

Vindoline, the major alkaloid of Catharanthus roseus , is a valuable anti-cancer agent and also acts as a precursor for other indole alkaloids. Although alkaloid biosynthesis does not normally take place in plant callus cultures, the presence of vindoline in C. roseus tissue has recently been implied from mass spectral data . In this report we autline some of our preliminary results which demonstrate that the callus of C. roseus is able to transform vindoline into deacetylvindoline

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