Abstract
To identify prognostic factors for curve progression in de novo degenerative lumbar scoliosis (DNDLS) by performing a systematic review of the literature. Studies were selected for inclusion following a systematic search in the bibliographic databases PubMed and EMBASE prior to September 2015 and hand searches of the reference lists of retrieved articles. Two authors independently assessed methodological quality. Data were extracted and presented according to a best evidence synthesis. The literature search generated a total of 2696 references. After removing duplicates and articles that did not meet inclusion criteria, 12 studies were included. Due to the lack of statistical analyses, pooling of data was not possible. Strong evidence indicates that increasing intervertebral disk degeneration, lateral vertebral translation ≥6mm, and an intercrest line through L5 (rather than L4) are associated with DNDLS curve progression. Moderate evidence suggests that apical vertebral rotation Grade II or III is associated with curve progression. For the majority of other prognostic factors, we found limited, conflicting, or inconclusive evidence. Osteoporosis, a coronal Cobb angle <30°, lumbar lordosis, lateral osteophytes difference of ≥5mm, and degenerative spondylolisthesis have not been shown to be risk factors. Clinical risk factors for progression were not identified. This review shows strong evidence that increased intervertebral disk degeneration, an intercrest line through L5, and apical lateral vertebral translation ≥6mm are associated with DNDLS curve progression. Moderate evidence was found for apical vertebral rotation (Grade II/III) as a risk factor for curve progression. These results, however, may not be directly applicable to the individual patient.
Highlights
The Global Burden of Disease Study has shown that low back pain has remained the leading cause for years lived with disability (YLD) in Western societies in the last two decades [1]
Strong evidence indicates that increasing intervertebral disk degeneration, lateral vertebral translation C6 mm, and an intercrest line through L5 are associated with de novo degenerative lumbar scoliosis (DNDLS) curve progression
For the majority of other prognostic factors, we found limited, conflicting, or Electronic supplementary material The online version of this article contains supplementary material, which is available to authorized users
Summary
The Global Burden of Disease Study has shown that low back pain has remained the leading cause for years lived with disability (YLD) in Western societies in the last two decades [1]. DNDLS causes an increasing burden on society in aging populations, with reduction in health related quality of life due to severe back and leg pain [9, 10]. Several studies have reported prevalence rates of 8.3, 8.9, and 13.3 % for adult scoliosis [16,17,18]. There is sufficient evidence to assume that the growing elderly population will result in an increase in prevalence rates of adult scoliosis [19,20,21,22]
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