Abstract
DDT inhibits the ATPase activity of the intact eel electroplaque. At a concentration of 10 −5 M, DDT inhibited 46% of the total ATPase activity, and 10 −4 M DDT inhibited 62% of the total ATPase activity and 62% of the ouabain-sensitive ATPase activity. The latter concentration of DDT reduced the rate of Na efflux from intact electroplaques and slowed the rate of recovery of the membrane potential following a large depolarization produced by carbamylcholine application. Repetitive direct stimulation of the innervated membrane at 10 Hz during the application of 10 −4 M DDT produced a significant irreversible depolarization. Ouabain, 10 −4 M, produced similar effects. The possible role of the inhibition of active NaK transport in producing the symptoms of DDT poisoning is discussed.
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