Abstract
A new method for estimation of renal concentrating performance by intranasal administration of DDAVP ( 1-deamino-8-D-arginine-vasopressin ) has been tested in 79 children and 25 infants. By comparative studies of different doses of intravenous and intranasal DDAVP it has been possible to elaborate a standard procedure using 20 μg DDAVP in children and 10 μg DDAVP in infants by tha intranasal route. The DDAVP-test with none or only moderate short-term fluidrestriction yields urine osmolality values equivalent to those after 22 hours of prolonged dehydration and significantly higher than those after combined pitreealn and fluid deprivation teat. In aliaear study of the urine concentrating performance postnatally in 28 infants as estimated by the DDAVP-test both lower maximum urine osmolality and shorter DDAVP-response Curves are found in preterm and asphyxiated babies. The lastmentioned observation is in agreement with the nephronic hetereogeneity with glomerular preponderance and small tubular mass at this age, but also indicates the effect of perinatal asphyxia upon tubular function.
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