Abstract
The genetics of colorectal cancer has been skillfully unravelled over the past decade. 1 Vogelstein B Fearon ER Kern SE et al. Allelotype of colorectal carcinomas. Science. 1989; 244: 207-211 Crossref PubMed Scopus (1178) Google Scholar The familial polyposis coli (APC) gene was localised to the short arm of chromosome 5. 2 Kinzler KW Nilbert MC Su LK et al. Identification of FAP locus genes from chromosome 5q21. Science. 1991; 253: 661-665 Crossref PubMed Scopus (1994) Google Scholar This gene codes a protein with three catenin-binding domains, two of which are encompassed by aminoacids 1129 to 1174. Truncated APC proteins larger than 80 kDa are able to form stable heterodimers which have reduced or absent tumour-suppressor activity. 3 Su LK Vogelstein B Kinzler KW Association of the tumour suppressor protein with catenins. Science. 1993; 262: 1734-1737 Crossref PubMed Scopus (1111) Google Scholar Later studies showed that this defect was but one of a series of putative mutations that may, in a sequential model, lead to sporadic colorectal cancer (table). 1 Vogelstein B Fearon ER Kern SE et al. Allelotype of colorectal carcinomas. Science. 1989; 244: 207-211 Crossref PubMed Scopus (1178) Google Scholar
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