Abstract
Results High expression of DC SIGN/R was observed on DCs infected with HIV-1 (p= 0.01). DC sIGNR expression in DCs was maximally downregulated by siRNA at 24 hrs (p=0.002) and was associated with significant reduction in expression of CD40 (p= 0.003), CD80 (p=0.008), CD86 (p=0.007) and P38 MAPK (p=0.005). Transfection of DC SIGNR on DCs at 24 hours followed by infection with clade C HIV-1 demonstrated lower levels of p24 compared to that in untransfected DCs (p=0.0008).
Highlights
Dendritic cells (DCs) capture HIV-1 from periphery via DC SIGN/R receptors and transfer to T cells
It has been reported that siRNA directed against DC SIGN significantly inhibits HIV infection of DCs
Submit your manuscript to BioMed Central and take full advantage of: Conclusion Data demonstrates that down regulation of Dendritic cells (DCs) SIGNR expression on DCs decreases activation that in turn may inhibit DC T cell interactions needed for progression of
Summary
Omkar Chaudhary[1], Sanjeev Kumar[1], Heena Aggarwal[1], Muzamil A Makhdoomi[1], Jasbir Singh[2,3], Anjali Hazarika[3], Kalpana Luthra1*. From 2nd International Science Symposium on HIV and Infectious Diseases (HIV SCIENCE 2014) Chennai, India. From 2nd International Science Symposium on HIV and Infectious Diseases (HIV SCIENCE 2014) Chennai, India. 30 January - 1 February 2014
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