Abstract
The effects of 24R,25-dihydroxycholecalciferol [24,25(OH)2 CC] on alkaline phosphatase (APA), gamma-glutamyltransferase (gamma-GT) and acid phosphatase (AP) activities were investigated on renal cortex slices of intact rats killed at 18h00 or at 06h00. At 06h00, three, six and nine hours after a single intraperitoneal injection of 24,25(OH)2 CC, APA activity was increased by 30%, 51% and 29%, respectively and gamma-GT activity, by 25%, 39% and 38%, as compared to their controls. AP on the other hand was not modified at all. These enzymatic stimulations were statistically higher than those measured at 18h00, respectively APA: 11%, 25%, 28% and gamma-GT: 2%, 20%, 22%. They can be explained by variations in new protein synthesis in relation with rat activity periods. Physiological significance of these renal effects remains to be elaborated.
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