David R. Spring

Abstract

Angewandte Chemie International EditionVolume 57, Issue 27 p. 7936-7936 Author ProfileFree Access David R. Spring First published: 26 January 2018 https://doi.org/10.1002/anie.201800487AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract “If I were not a scientist, I would be a florist. My favorite author (fiction) is J. K. Rowling ...” This and more about David R. Spring can be found on page 7936. David R. Spring The author presented on this page has recently published his 10th article in Angewandte Chemie in the last 10 years: “Targeting the Genome-Stability Hub Ctf4 by Stapled-Peptide Design”: Y. Wu, F. Villa, J. Maman, Y. H. Lau, L. Dobnikar, A. C. Simon, K. Labib, D. R. Spring, L. Pellegrini, Angew. Chem. Int. Ed. 2017, 56, 12866; Angew. Chem. 2017, 129, 13046. Position: University Professor, University of Cambridge E-mail: spring@ch.cam.ac.uk Homepage: http://www-spring.ch.cam.ac.uk ORCID: 0000-0001-7355-2824 Education: 1995 BA in chemistry, University of Oxford 1998 DPhil supervised by Jack E. Baldwin, University of Oxford 1999–2001 Postdoctoral fellow with Stuart L. Schreiber, Harvard University Awards: 2010 Discovery Chemistry and New Technologies Award, Royal Society of Chemistry (RSC); 2011 Norman Heatley Award, RSC; 2013 Félix Serratosa Lecture, IQAC–CSIC Barcelona and RSEQ Tarragona, organized by the Societat Catalana de Química and Real Sociedad Española de Química; 2014 Corday–Morgan Award, RSC Current research interests: Diversity-oriented synthesis; protein–protein interactions; quorum sensing; new antibiotics; next-generation therapeutics If I were not a scientist, I would be a florist. My favorite author (fiction) is J. K. Rowling. My top three films of all time are North by Northwest, The Third Man, and Star Wars. The downside of my job is saying goodbye to amazing co-workers after they have graduated or have been offered jobs in industry. In retrospect I would never again eat the pink blancmange with sweetcorn pudding that my postdoc brought in to group meeting. My favorite food is vegemite. If I won the lottery, I would give the money away (after a nice holiday). My favorite place on earth is Cambridge (UK). My greatest achievement has been helping educate so many talented students in chemistry and research. I hope I have passed on my enthusiasm for chemistry and its potential in understanding and treating disease. The most exciting thing about my research is being able to test small molecules in biological assays, which leads to enhanced understanding of biology and improved medicines. Guaranteed to make me laugh is the news and current-affairs magazine Private Eye. The worst advice I have ever been given was to let my research group provide some of the answers to this Author Profile. I celebrate success by drinking sparkling beverages. I would have liked to have discovered penicillin. My 5 top papers: 1“Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides”: Y. H. Lau et al., Angew. Chem. Int. Ed. 2015, 54, 15410; Angew. Chem. 2015, 127, 15630. (Cell-permeable, stapled peptides can have a dramatic biological effect by selectively inhibiting a specific protein–protein interaction.) 2“A strategy for the diversity-oriented synthesis of macrocyclic scaffolds using multidimensional coupling”: H. S. G. Beckmann, F. Nie, C. E. Hagerman, H. Johansson, Y. S. Tan, D. Wilcke, D. R. Spring, Nature Chem. 2013, 5, 861. (The idea of multidimensionality in efficient diversity generation is elegantly illustrated.) 3“Anti-MRSA Agent Discovery Using Diversity-Oriented Synthesis”: G. L. Thomas et al., Angew. Chem. Int. Ed. 2008, 47, 2808; Angew. Chem. 2008, 47, 2808; Angew. Chem. 2008, 120, 2850. (An early illustration of the potential of diversity-oriented synthesis by some of my first group members.) 4“Diversity-Oriented Synthesis Of Biaryl-Containing Medium Rings Using A One Bead/One Stock Solution Platform”: D. R. Spring, S. Krishnan, H. E. Blackwell, S. L. Schreiber, J. Am. Chem. Soc. 2002, 124, 1354. (The main part of my postdoc work with Stuart Schreiber.) 5“Investigations into the Manzamine Alkaloid Biosynthetic Hypothesis”: J. E. Baldwin et al., Angew. Chem. Int. Ed. 1998, 37, 2661; Angew. Chem. 1998, 110, 2806. (This was the main part of my DPhil work with Jack Baldwin.) Volume57, Issue27July 2, 2018Pages 7936-7936 ReferencesRelatedInformation