Abstract
David R. Liu is an inventor on a winning streak. As a young chemist, he quickly mastered techniques for studying life’s most complex molecules and then turned to altering the building blocks of life itself. He repurposed the genetic code of DNA to create large libraries of small molecules for drug screening and created a system for engineering new proteins that’s at least 100 times as fast as previous methods. Most recently, Liu is leading the charge in conceiving improved versions of CRISPR, the gene-editing tool that is revolutionizing research. His most notable advance is a new “base editor” that can swap a single nucleotide base, or letter, of DNA for another. The invention opens the door to developing treatments for the thousands of genetic diseases caused by one small typo in DNA. “He’s going to be the godfather of CRISPR 2.0,” says Gerald Joyce, director of the Genomics Institute
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