Abstract
This review analyzes current studies of the therapeutic effects of Phoenix dactylifera, or date palm fruit, on the physiologic system. Specifically, we sought to summarize the effects of its application in preventing cell damage, improving cancer therapeutics and reducing damage caused by conventional chemotherapy. Phoenix dactylifera exhibits potent anti-oxidative properties both in vitro and in vivo. This allows the fruit to prevent depletion of intrinsic protection from oxidative cell damage and assist these defense systems in reducing cell damage. Macroscopically, this mechanism may be relevant to the prevention of various adverse drug events common to chemotherapy including hepatotoxicity, nephrotoxicity, gastrotoxicity, and peripheral neuropathy. While such effects have only been studied in small animal systems, research suggests a potential application to more complex mammalian systems and perhaps a solution to some problems of chemotherapy in hepato-compromised and nephro-compromised patients.
Highlights
Cancer has long existed as a key task on the agenda of the United States Health Services
An examination of the available information on cancer incidence in countries where dates are widely consumed as a staple food source shows that Saudi Arabia, the world’s second largest producer of dates, rates “tumors” as fifth in their top 10 diseases according to the World Health Organization [5] and ranks far below the USA and the rest of the world for age-standardized rates of cancer incidence and mortality in males and females [6,7,8]
The World Health Organization has stated that the evidence supporting a decreased risk of developing cancer due to polyphenols, currently labeled ‘non-nutrient plant constituents’, is possible, but insufficient [49]. This puts the onus of responsibility on researchers to further explore the potential of these substances in cancer therapeutics
Summary
An examination of the available information on cancer incidence in countries where dates are widely consumed as a staple food source shows that Saudi Arabia, the world’s second largest producer of dates, rates “tumors” as fifth in their top 10 diseases according to the World Health Organization [5] and ranks far below the USA and the rest of the world for age-standardized rates of cancer incidence and mortality in males and females [6,7,8]. Toxicity-related studies were limited to in vivo animal and human studies
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