Date Palm (Phoenix dactylifera) Fruits as a Potential Cardioprotective Agent: The Role of Circulating Progenitor Cells.

Ibrahim A Alhaider,Maged E Mohamed,K K M Ahmed,Arun H S Kumar

doi:10.3389/fphar.2017.00592

Ibrahim A Alhaider, Maged E Mohamed + Show 2 more

Open Access

https://doi.org/10.3389/fphar.2017.00592

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Abstract

Context: Date palms, along with their fruits’ dietary consumption, possess enormous medicinal and pharmacological activities manifested in their usage in a variety of ailments in the various traditional systems of medicine. In recent years, the identification of progenitor cells in the adult organ systems has opened an altogether new approach to therapeutics, due to the ability of these cells to repair the damaged cells/tissues. Hence, the concept of developing therapeutics, which can mobilize endogenous progenitor cells, following tissue injury, to enhance tissue repair process is clinically relevant.Objectives: The present study investigates the potential of date of palm fruit extracts in repairing tissue injury following myocardial infarction (MI) potentially by mobilizing circulating progenitor cells.Methods: Extracts of four different varieties of date palm fruits common in Saudi Arabia eastern provision were scrutinized for their total flavonoid, total phenolic, in vitro antioxidant capacity, as well as their effects on two different rodent MI models.Results: High concentrations of phenolic and flavonoid compounds were observed in date palm fruit extracts, which contributed to the promising antioxidant activities of these extracts and the observed high protective effect against various induced in vivo MI. The extracts showed ability to build up reserves and to mobilize circulating progenitor cells from bone marrow and peripheral circulation to the site of myocardial infraction.Conclusion: Date palm fruit extracts have the potential to mobilize endogenous circulating progenitor cells, which can promote tissue repair following ischemic injury.

Highlights

Despite tremendous growth in pharmacotherapy of myocardial infarctions (MIs), mortality continues to rise (Caplice and Doyle, 2005; Saleem et al, 2008; Nofal and Abdulmohsen, 2010)
The results showed that isoproterenol hydrochloride (ISO) has already induced the state of MI as appeared in the levels of serum and tissue biomarkers (Table 1) as well as from the histopathological examination (Figure 3)
Pretreated with dates extract (D1–D4) for a period of 28 days prior to isoproterenol injection significantly improved the state of MI and this can be suggested from the levels of tissue and serum biomarker, which shows significant difference from the ISO control group (Table 1)

Summary

Introduction

Despite tremendous growth in pharmacotherapy of myocardial infarctions (MIs), mortality continues to rise (Caplice and Doyle, 2005; Saleem et al, 2008; Nofal and Abdulmohsen, 2010). The discovery that pluripotent progenitor cells (stem cells) bearing the capacity to differentiate into mature cardiac cells raised the hope of cell-based regenerative medicine (Saleem et al, 2008). Several adult and embryonic precursor cell populations have reported to differentiate the vascular cell phenotype and participate in a range of biological repair functions within the cardiovascular system. The cell therapy era as moved from the preclinical arena to the clinical phase, wherein potential benefits are widely reported with the use of progenitor cells in the context of cardiovascular disorders, especially MI. Considerable preclinical work is needed to further refine the progenitor cell therapy-based medicine (Kawamoto and Asahara, 2007; Jujo et al, 2008; Yamahara and Itoh, 2009; Adamo and Garcia-Cardena, 2012; Brunt et al, 2012)

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