Dataset on effects of perinatal exposure to propylthiouracil on serum T4, body weight gain, day of eye opening and brain monoamine contents in offspring mice

Toyoshi Umezu,Taizo Kita,Masatoshi Morita

doi:10.1016/j.dib.2019.104900

Abstract

Physical growth and brain development need sufficient thyroid hormone (TH). This dataset describes serum T4 level, body weight gain and day of eye opening in offspring mice exposed to the TH synthesis inhibitor propylthiouracil (PTU) from gestational day (GD) 15 to postnatal day (PND) 25. This dataset also describes content of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), 3-methoxytyramine (3-MT), 5-HT, and 5-hydroxyindoleacetic acid (5-HIAA) and their turnover in the hypothalamus, hippocampus, and nucleus accumbens of male offspring mice perinatally exposed to PTU. These data are referred by a research article entitled “Hyperactive behavioral phenotypes and an altered brain monoaminergic state in male offspring mice with perinatal hypothyroidism” [1].

Highlights

Dataset on effects of perinatal exposure to propylthiouracil on serum T4, body weight gain, day of eye opening and brain monoamine contents in offspring mice
Physical growth and brain development need sufficient thyroid hormone (TH). This dataset describes serum T4 level, body weight gain and day of eye opening in offspring mice exposed to the TH synthesis inhibitor propylthiouracil (PTU) from gestational day (GD) 15 to postnatal day (PND) 25
This dataset describes content of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), 3-methoxytyramine (3-MT), 5HT, and 5-hydroxyindoleacetic acid (5-HIAA) and their turnover in the hypothalamus, hippocampus, and nucleus accumbens of male offspring mice perinatally exposed to PTU

Summary

Specifications Table

Toxicology Development of brain monoaminergic system and hypothyroidism Figures and Tables Observation and body weight measurement Radioimmunoassay using DPC・total T4 kits (Yatoron Co., Ltd. (present: LSI Medience Co., Ltd.), Tokyo, Japan) High performance liquid chromatography system (L-5000; Yanaco, Kyoto, Japan) with a 4.6 mm Â 250 mm ODS-C18 column (Nacalai, Kyoto, Japan) and an electrochemical detector (VMD-101A; Yanaco) including a glassy carbon electrode. Toxicology Development of brain monoaminergic system and hypothyroidism Figures and Tables Observation and body weight measurement Radioimmunoassay using DPC・total T4 kits Drug Propylthiouracil (6-Propyl-2-thiouracil or 2,3-Dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinone; PTU) solution at concentrations of 125, 250, or 500 ppm was given as drinking water to pregnant females

Experimental procedures

Statistical analyses