Abstract
Data on the allele and genotype frequencies of the three functionally significant single nucleotide polymorphisms (SNPs) of the matrix metalloproteinases (MMP) genes (rs1799750 MMP1, rs3918242 and rs17576 MMP9) in Russian patients with primary open-angle glaucoma (POAG), essential hypertension (EH) and peptic ulcer (PU) are presented. Association studies identified these SNPs as possible significant markers associated with many multifactorial disorders, including POAG, EH, and PU. The frequencies of alleles and genotypes of the three SNPs in Russian patients with POAG, EH, and PU were presented separately for the entire study sample, females, and males, respectively. The data can be used as a reference for the Russian population.
Highlights
Data on the allele and genotype frequencies of the three functionally significant single nucleotide polymorphisms (SNPs) of the matrix metalloproteinases (MMP) genes in Russian patients with primary open-angle glaucoma (POAG), essential hypertension (EH) and peptic ulcer (PU) are presented
The polymorphisms rs1799750 MMP1, rs3918242 and rs17576 MMP9 may be associated with POAG, EH, and PU
The data on the allele and genotype frequencies of the MMP genes can be used for metaanalyses of genetic studies on POAG, EH, and PU
Summary
The dataset contains the raw data (supplementary Table), frequencies of alleles and genotypes (Table 1) for three SNPs of two MMP genes (rs1799750 MMP1, rs3918242 and rs17576 MMP9) in Russian patients diagnosed with POAG, EH, and PU These polymorphisms were previously reported for their association with POAG, EH, and PU (Table 2) [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45]. No significant differences in the frequencies of alleles and genotypes were found between the male and female participants for each of the studied diseases
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