Abstract
Weekly submission of rats to active avoidance apparatus can be considered a neurostimulation strategy, once it can improve memory and can increase the density of receptors from different neurotransmitter systems in brain areas related to memory. These benefits were observed in rats chronically infused with amyloid-β peptide. In the present work it is presented that the same benefit for memory was observed in five months old transgenic mice for Alzheimer’s disease (TG-PDGFB-APPSw,Ind). However, at this age, no change in density of nicotinic receptors was observed.
Highlights
Dataset for the role of sustained attention in memory formation of transgenic mice for Alzheimer's disease
Submission of rats to active avoidance apparatus can be considered a neurostimulation strategy, once it can improve memory and can increase the density of receptors from different neurotransmitter systems in brain areas related to memory
In the present work it is presented that the same benefit for memory was observed in five months old transgenic mice for Alzheimer’s disease (TG-PDGFB-APPSw,Ind)
Summary
Animals were weekly stimulated in the active avoidance (two-way) shuttle-box during six weeks. In the first two weeks, transgenic mice showed 40.6% and 45.4%, respectively, less conditioned avoidance responses (CAR) than WT control animals (Fig. 1). The animals showed an increase in CAR percentage, getting similar to the WT behavior
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