Database and interaction network of genes involved in oral cancer: Version II.

Nikhil Sureshkumar Gadewal,Surekha Mahesh Zingde

doi:10.6026/97320630006169

Abstract

The oral cancer gene database has been compiled to enable fast retrieval of updated information and role of the genes implicated in oral cancer. The first version of the database with 242 genes was published in Online Journal of Bioinformatics 8(1), 41-44, 2007. In the second version, the database has been enlarged to include 374 genes by adding 132 gene entries. The architecture and format of the database is similar to the earlier version, and includes updated information and external hyperlinks for all the genes. The functional gene interaction network for important biological processes and molecular functions has been rebuilt based on 374 genes using 'String 8.3'. The database is freely available at http://www.actrec.gov.in/OCDB/index.htm and provides the scientist information and external links for the genes involved in oral cancer, interactions between them, and their role in the biology of oral cancer along with clinical relevance.

Highlights

Head and neck cancer is the sixth common malignancy and is the major cause of cancer morbidity and mortality worldwide
The database published in 2007 [1] was updated by adding 132 new genes searched from the PubMed database using the MESH words “genes AND oral cancer”
Genes which are not mentioned in the PUBMED abstracts were obtained from 10 full-text articles for proteomics studies retrieved using MESH words “oral cancer AND proteomics” and “oral cancer and autoantibodies” [28] as well as from “head and neck cancer AND proteomics” and “head and neck cancer AND autoantibodies” [9,10,11]

Summary

Introduction

Head and neck cancer is the sixth common malignancy and is the major cause of cancer morbidity and mortality worldwide. In the present database the genes which are listed are reported to be altered in oral cancer. The genes are presented in alphabetical order in the gene-list, with links to the gene-info page wherein detailed information of the gene is available through hyperlinks which connect to specific databases for complete information.

Results

Conclusion