Data_Sheet_1.PDF

Abstract

BACKGROUND: As an important autoimmune disease, type 1 diabetes (T1D) is often diagnosed in children, but due to the complexity of the etiology of diabetes and many other factors, the disease pathogenesis of diabetes is still unclear. Intestinal microbiota has been proved to have close relationships with T1D, which is one of the most important molecular bases of pathogenesis and prognosis factors for T1D. By using the multiomics and multicenter sample analysis method, a number of intestinal microbiota in T1D has been discovered and explained, which has provided comprehensive and rich information. However, how to find more useful information and get an intuitive understand that people need conveniently in the huge data sea has become the focus of attention. Therefore, quantitative analysis and visualization of the interaction between intestinal microbiota and T1D in children are urgently needed. METHODS: We retrieved the detailed original data from NCBI, GMREPO, gutMEGA database and other authoritative multiple projects BioProject: PRJNA289586/445932/387903) with related research, the ranking of intestinal microbiota abundance from healthy people, overall T1D patients and T1D in children were detailed analyzed, classified and visualized. RESULTS: A total of 515 bacterial species and 161 related genus were fully analyzed. And Prevotella copri was led by 21.25% average abundance followed by Clostridium tertium of 10.39% in all-cross T1D patients. For children with T1D, Bacteroides vulgatus has high abundance in all age periods while the abundance of each intestinal microbiota was more uniform in female samples, with the ranking from high to low as Bacteroides dorei 9.56%, Prevotella copri 9.53%, Streptococcus pasteurianus 8.15%, Clostridium tertium 7.53% while in male samples Prevotella copri was accounted by 22.72%. The interaction between intestinal microbiota and comparison between healthy people and children with T1D was also detailed analyzed. CONCLUSIONS: This study provides a new method and comprehensive perspectives for the evaluation of interaction between intestinal microbiota and T1D in children. A set of useful information of intestinal microbiota with its internal interaction and connections has been presented, which could be a compact, immediate and practical scientific reference for further molecular biological and clinical translational research of T1D in children.