Data_Sheet_1.docx

Abstract

The COVID-19 disease is a multisystem disease due to in part to the vascular endothelium injury. Lasting effects and long -term sequalae could persist after the infection and may be due to persistent endothelial dysfunction. Our study focused on the evaluation of endothelial quality index (EQI) by finger thermal monitoring with E4 diagnosis Polymath in a large cohort of long COVID-19 patients to determine whether long-covid 19 symptoms are associated to endothelial dysfunction. This is a cross sectional multicenter observational study with a prospective recruitment of patients. A total of 798 patients were included in this study. A total of 618 patients (77.4%) had long COVID-19 symptoms. The mean EQI was 2.02 ± 0.99 IC95% [1.95 – 2.08]. A total of 397 (49.7%) patients had impaired EQI. Fatigue, chest pain and neuro-cognitive difficulties were significantly associated to endothelium dysfunction with an EQI <2 after adjustment with age, sex, diabetes, hypertension, dyslipidemia, coronary heart disease and the severity of acute COVID-19 infection. In multivariate analysis, endothelial dysfunction (EQI < 2), female gender and severe clinical status at acute COVID-19 infection with a need to oxygen supplementation were independent risk factors of long COVID-19 syndrome. Long COVID-19 symptoms specifically non-respiratory symptoms are due to persistent endothelial dysfunction. These findings allow a better care of patients with long COVID-19 symptoms.