Abstract
Di (2-ethylhexyl) phthalate (DEHP) is used as plasticizer in the industry and belongs to the phthalate family which can induce tissue damage including kidney, liver, and testis as a result of elevated oxidative stress levels. Glutathione reductase (GR), Glucose-6-phosphate dehydrogenase (G6PD), glutathione S-transferase (GST), 6-phosphogluconate dehydrogenase (6PGD), enzyme activities, trace element and mineral levels were evaluated in the brain and testis tissue samples. Our data revealed that, antioxidant enzyme activities in the brain and testis samples were statistically insignificant in the DEHP administered groups compared to the control group except 400 mg/kg/day DEHP dose group in the testis samples. DEHP can disrupt trace element and mineral levels unlike antioxidant enzyme levels that may due to blood-brain and testis-blood barrier and/or short-term exposure to the DEHP. For more detailed information than the data presented in this article, please see the research article “Impact of the Di (2-Ethylhexyl) Phthalate Administration on Trace Element and Mineral Levels in Relation of Kidney and Liver Damage in Rats” [1].
Highlights
Data the Di (2-ethylhexyl) phthalate (DEHP) induced changes on the trace element and mineral levels in the brain and testis tissues of rats
Glutathione reductase (GR), Glucose-6-phosphate dehydrogenase (G6PD), glutathione S-transferase (GST), 6-phosphogluconate dehydrogenase (6PGD), enzyme activities, trace element and mineral levels were evaluated in the brain and testis tissue samples
For more detailed information than the data presented in this article, please see the research article “Impact of the Di (2-Ethylhexyl) Phthalate Administration on Trace Element and Mineral Levels in Relation of Kidney and Liver Damage in Rats” [1]
Summary
Biology Endocrine disrupting chemicals (EDCs) Graphs Tables Spectrophotometer, ICP-MS Microwave digestion Animal experiments Raw and Analyzed Rats were exposed to the DEHP administration (0, 100, 200 and 400 mg/kg/day). ICP-MS data is useful for the information about DEHP-induced changes in the trace element and mineral levels These data are relevant in both toxicology and biochemistry research, especially for the understanding of effects on the endocrine disrupting chemicals on the tissues with the blood-tissue barrier. GR enzyme activity significantly increased in the 400 mg/kg DEHP treated group compared to the control (Fig. 2, Table 2). In this frame, we can say that the testis is more affected than brain upon DEHP. Sodium (Na), magnesium (Mg), potassium (K), rubidium (Rb) and iron (Fe) levels significantly increased in 400 mg/kg/day DEHP treated groups compared to the control in rat brain tissue samples. DEHP impair mineral and trace element levels in the brain and tissue samples that may cause disease formation in long term exposure
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