Data sample size needed for analysis of kinematic and muscle synergies in healthy and stroke populations.

Abstract

Multiple studies have suggested the central nervous system (CNS) generates motions by using modular control of muscles and joints (synergies). However, the synergies reported by these studies are task dependent and might not reflect the true control strategies adopted by the CNS. Studying exploratory motions (EMs) can reveal biomechanical constraints and motor control strategies in healthy and clinical populations. The first logical step to consider EMs in study of motor synergies is to determine how much data is required to reliably and fully profile the motion patterns of an individual. Here we present how the quality of motor synergies analysis depends on the amount of EM data included in the analysis. We recruited 10 healthy and 10 post-stroke participants and collected electromyography (EMG) and joint motion data of their arms as they completed a motor exploration task. We compared the effects of clinical status and limb strength/dominance on the amount of data required to identify synergies. Clinical status had a significant elïect on the required amount of data for both datasets. Limb strength had a significant effect only for kinematic data. We determined the upper bound 95% confidence interval to set the amount of data required for synergy analysis in both populations: 235 sec for EMG data and 265 sec for kinematic data. Our results provide an important step toward using motor exploration in the study of healthy motor synergies and how stroke alters them.