Abstract
As part of the Avon Longitudinal Study of Parents and Children (ALSPAC), measures of child IQ were collected by trained psychologists. The Wechsler Pre-school and Primary Scale of Intelligence – Revised UK edition (WPPSI) was used at age 4 years in a subsample of children enrolled in ALSPAC (the Children in Focus cohort), chosen at random from the last 6 months of ALSPAC births (about 10% of the participants). At age 8 years all children enrolled in the main cohort were invited to complete a short form of the Wechsler Intelligence Scale for Children (WISC)-III UK. Prenatal blood lead (B-Pb) concentrations were measured by inductively-couple plasma mass spectrometry in samples from women at a median gestation age of 11 weeks. Child blood lead was measured by atomic absorption spectrometry in samples from children attending the Children in Focus clinic at age 30 months. Maternal reports at 32 weeks’ gestation were used to generate data on a range of potential confounders. The data were used to determine the associations between prenatal exposure to lead and child IQ at 4 and 8 years. The effect of child B-Pb at 3 years as a moderator of these associations was tested. (For results, please see doi:10.1016/j.neuro.2017.07.003 Taylor et al., (2017)).
Highlights
Data relating to prenatal lead exposure and child IQ at 4 and 8 years old in the Avon Longitudinal Study of Parents and Children
We describe data on child IQ at 4 and 8 years, prenatal B-Pb concentrations and child B-Pb concentrations at age 2.5 years
Associations of maternal smoking and alcohol consumption were similar to those for paternal smoking and alcohol consumption, suggesting effect not explained by intrauterine exposure Maternal mild-to-moderate iodine deficiency associated with likelihood of child being in the lowest quartile of verbal IQ No association
Summary
Associations of maternal smoking and alcohol consumption were similar to those for paternal smoking and alcohol consumption, suggesting effect not explained by intrauterine exposure Maternal mild-to-moderate iodine deficiency associated with likelihood of child being in the lowest quartile of verbal IQ No association. No association of maternal fasting glucose genetic risk score Positive association of maternal type 2 diabetes genetic risk score Positive association of being in the ‘fruit and vegetable’ cluster on child IQ compared with the ‘meat and potato’ cluster and the ‘white bread and coffee’ cluster No association providing the mother consumes fish. Positive association of moderate drinking compared with light drinking on child IQ, possibly reflecting residual confounding
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